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KMID : 0811719990030010069
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Korean Journal of Physiology & Pharmacology
1999 Volume.3 No. 1 p.69 ~ p.74
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Systemic Injection of Lidocaine Induce Expression of c-fos mRNA and Protein in Adult Rat Brain
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Han-Jung Chae
Jang-Sook Kang/Seoung-Bum Cho/Byung-Gwan Jin/Suk-Jun Won3/Byung-Joo Gwag/Hyung-Ryong Kim
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Abstract
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Both direct and indirect environmental stress to brain were increase the expression of transcription factor c-fos in various populations of neurons. In this study, we examined whether the intraperitoneal injections of lidocaine at doses inducing convulsion within 10 min increased the level of c-fos mRNA and protein in forebrain areas. In situ hybridization using [35S]UTP?labeled antisense c-fos, cRNA increased c-fos mRNA levels though hippocampal formation, piriform cortex, septum, caudate-putamen, neostriatum, and amygdala within 2 hr. In parallel with the mRNA expression, c-FOS protein immunoreactivity was also observed in the same forebrain areas. In contrast to the seizure activity and widespread neuronal degeneration following a kainate treatment, injections of lidocaine did not produce neuronal death within 3 days. The present study indicates that lidocaine induces convulsion and c-fos expression without causing neurotoxicity.
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KEYWORD
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Transcription factor, c-fos mRNA and protein, Neurotoxicity,
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